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flezurafenib   Click here for help

GtoPdb Ligand ID: 13233

Synonyms: compound A-1 [WO2022023450]
Compound class: Synthetic organic
Comment: The chemical structure for flezurafenib was obtained from proposed INN list 130 (Feb. 2024), in which the compound is described as a rapidly accelerated fibrosarcoma (Raf) kinase inhibitor with proposed antineoplastic action. It is one of the Raf inhibitors claimed in patent WO2022023450A1 [1]. Investigation of Jazz Pharmaceuticals' pipeline suggests that flezurafenib may be their oral pan-Raf inhibitor clinical lead JZP815. This lead is being explored for efficacy against solid tumours and haematologic malignancies harbouring oncogenic mutations that activate the RAS-RAF-MAPK pathway. We will update this entry when the structure for flezurafenib or JZP815 is publicly disclosed.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Click here for structure editor
Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 84.31
Molecular weight 456.47
XLogP 0.92
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES C1=CC(=CC=C1C2=CNC(=N2)[C@@H]3CC4=CC(=CC=C4OC3)OC5=CC=NC6=C5CCC(=O)N6)F
Isomeric SMILES FC1=CC=C(C=C1)C=2N=C(NC2)[C@H]3COC4=C(C3)C=C(C=C4)OC5=C6CCC(NC6=NC=C5)=O
InChI InChI=1S/C26H21FN4O3/c27-18-3-1-15(2-4-18)21-13-29-25(30-21)17-11-16-12-19(5-7-22(16)33-14-17)34-23-9-10-28-26-20(23)6-8-24(32)31-26/h1-5,7,9-10,12-13,17H,6,8,11,14H2,(H,29,30)(H,28,31,32)/t17-/m1/s1
InChI Key TWJSMWXWCWQPRO-QGZVFWFLSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Bioactivity Comments
Inhibition of ERK phosphorylation in cancer cell lines by flezurafenib (compound A-1) is reported in patent WO2022023450A1 [1]. The patent does not provide potency values for inhibition of RAF kinases.