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MDOLL-0229   Click here for help

GtoPdb Ligand ID: 13321

Synonyms: compound 27 [PMID: 38592023] | MDOLL0229
PDB Ligand
Compound class: Synthetic organic
Comment: MDOLL-0229 is a small molecule SARS-CoV-2 Mac1 domain inhibitor [1]. Mac1 is a domain encoded in the nsp3 region of the virus' polyprotein. It is proposed to have ADP-ribosylhydrolase activity that is associated with the virus' actions to suppress host IFN production and support viral survival.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 118
Molecular weight 393.5
XLogP 3.29
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES COC(=O)C1=C(NC(=O)[C@@H]2CCCC[C@H]2C(=O)O)SC3=C1CCCCCC3
Isomeric SMILES COC(=O)C=1C2=C(SC1NC(=O)[C@H]3[C@@H](CCCC3)C(=O)O)CCCCCC2
InChI InChI=1S/C20H27NO5S/c1-26-20(25)16-14-10-4-2-3-5-11-15(14)27-18(16)21-17(22)12-8-6-7-9-13(12)19(23)24/h12-13H,2-11H2,1H3,(H,21,22)(H,23,24)/t12-,13-/m1/s1
InChI Key FLTXXOCJBMXERF-CHWSQXEVSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
(1R,2R)-2-[(3-methoxycarbonyl-4,5,6,7,8,9-hexahydrocycloocta[b]thiophen-2-yl)carbamoyl]cyclohexane-1-carboxylic acid
Synonyms Click here for help
compound 27 [PMID: 38592023] | MDOLL0229
Database Links Click here for help
GtoPdb PubChem SID 496703291
PubChem CID 1358501
RCSB PDB Ligand VI1
Search Google for chemical match using the InChIKey FLTXXOCJBMXERF-CHWSQXEVSA-N
Search Google for chemicals with the same backbone FLTXXOCJBMXERF
UniChem Compound Search for chemical match using the InChIKey FLTXXOCJBMXERF-CHWSQXEVSA-N
UniChem Connectivity Search for chemical match using the InChIKey FLTXXOCJBMXERF-CHWSQXEVSA-N