exeporfinium   Click here for help

GtoPdb Ligand ID: 13323

Synonyms: XF-73 (exeporfinium chloride)
Compound class: Synthetic organic
Comment: Exeporfinium is a novel dicationic porphyrin antibacterial compound with activity against a wide range of Gram-positive bacteria, including Staphylococcus aureus [2,4]. We show the structure of the parent molecule here. The INN represents the chloride salt form (XF-73, CAS number 718638-68-7) and this is also the form that is under clinical evaluation.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 12
Topological polar surface area 67.24
Molecular weight 694.91
XLogP 3.7
No. Lipinski's rules broken 2

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES C[N+](C)(C)CCCOC1=CC=C(C=C1)C2=C3C=CC(=N3)C=C4C=CC(=C(C5=CC=C(C=C5)OCCC[N+](C)(C)C)C6=NC(=CC7=CC=C2N7)C=C6)N4
Isomeric SMILES C[N+](C)(C)CCCOC1=CC=C(C=C1)C2=C3C=CC(=CC4=NC(=C(C5=CC=C(N5)C=C6C=CC2=N6)C7=CC=C(C=C7)OCCC[N+](C)(C)C)C=C4)N3
InChI InChI=1S/C44H50N6O2/c1-49(2,3)25-7-27-51-37-17-9-31(10-18-37)43-39-21-13-33(45-39)29-35-15-23-41(47-35)44(42-24-16-36(48-42)30-34-14-22-40(43)46-34)32-11-19-38(20-12-32)52-28-8-26-50(4,5)6/h9-24,29-30,45,48H,7-8,25-28H2,1-6H3/q+2
InChI Key KZTXNPVFWHWJSH-UHFFFAOYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
References
1. Farrell DJ, Robbins M, Rhys-Williams W, Love WG. (2010)
In vitro activity of XF-73, a novel antibacterial agent, against antibiotic-sensitive and -resistant Gram-positive and Gram-negative bacterial species.
Int J Antimicrob Agents, 35 (6): 531-6. [PMID:20346634]
2. Maisch T, Bosl C, Szeimies RM, Lehn N, Abels C. (2005)
Photodynamic effects of novel XF porphyrin derivatives on prokaryotic and eukaryotic cells.
Antimicrob Agents Chemother, 49 (4): 1542-52. [PMID:15793136]
3. Mangino JE, Firstenberg MS, Milewski RKC, Rhys-Williams W, Lees JP, Dane A, Love WG, Gonzalez Moreno J. (2023)
Exeporfinium chloride (XF-73) nasal gel dosed over 24 hours prior to surgery significantly reduced Staphylococcus aureus nasal carriage in cardiac surgery patients: Safety and efficacy results from a randomized placebo-controlled phase 2 study.
Infect Control Hosp Epidemiol, 44 (7): 1171-1173. [PMID:36951472]
4. Ooi N, Miller K, Hobbs J, Rhys-Williams W, Love W, Chopra I. (2009)
XF-73, a novel antistaphylococcal membrane-active agent with rapid bactericidal activity.
J Antimicrob Chemother, 64 (4): 735-40. [PMID:19689976]
5. Ooi N, Miller K, Randall C, Rhys-Williams W, Love W, Chopra I. (2010)
XF-70 and XF-73, novel antibacterial agents active against slow-growing and non-dividing cultures of Staphylococcus aureus including biofilms.
J Antimicrob Chemother, 65 (1): 72-8. [PMID:19889790]