Ru265   Click here for help

GtoPdb Ligand ID: 13350

Compound class: Synthetic organic
Comment: Ru265 is a small bi-nuclear ruthenium-containing complex that has a similar chemical structure to Ru360, however unlike its predecessor Ru265 is cell-permeable and is therefore suitable for in vitro studies in intact cells. Ru265 inhibits mitochondrial Ca2+ uptake by disrupting Ca2+ movement through the mitochondrial calcium uniporter (MCU; Q8NE86) [1-3].
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 1
Hydrogen bond donors 8
Rotatable bonds 1
Topological polar surface area 233.48
Molecular weight 423.29
XLogP 1.18
No. Lipinski's rules broken 1

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES Cl[Ru-3](=N[Ru-2](Cl)([NH3+])([NH3+])([NH3+])[NH3+])([NH3+])([NH3+])([NH3+])[NH3+]
Isomeric SMILES [NH3+][Ru-3]([NH3+])([NH3+])([NH3+])(Cl)=N[Ru-2]([NH3+])([NH3+])([NH3+])(Cl)[NH3+]
InChI InChI=1S/2ClH.8H3N.N.2Ru/h2*1H;8*1H3;;;/q;;;;;;;;;;;+2;+3/p-2
InChI Key UXYFPGFFYRVBGS-UHFFFAOYSA-L

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
References
1. Baughman JM, Perocchi F, Girgis HS, Plovanich M, Belcher-Timme CA, Sancak Y, Bao XR, Strittmatter L, Goldberger O, Bogorad RL et al.. (2011)
Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter.
Nature, 476 (7360): 341-5. [PMID:21685886]
2. De Stefani D, Raffaello A, Teardo E, Szabò I, Rizzuto R. (2011)
A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter.
Nature, 476 (7360): 336-40. [PMID:21685888]
3. Woods JJ, Nemani N, Shanmughapriya S, Kumar A, Zhang M, Nathan SR, Thomas M, Carvalho E, Ramachandran K, Srikantan S et al.. (2019)
A Selective and Cell-Permeable Mitochondrial Calcium Uniporter (MCU) Inhibitor Preserves Mitochondrial Bioenergetics after Hypoxia/Reoxygenation Injury.
ACS Cent Sci, 5 (1): 153-166. [PMID:30693334]