trovafloxacin   Click here for help

GtoPdb Ligand ID: 13476

Synonyms: CP-99,219 | Trovan® | Turvel®
Approved drug
trovafloxacin is an approved drug (FDA (1997), EMA (1998))
Compound class: Synthetic organic
Comment: Trovafloxacin is a 1,8-naphthyridine derivative, structurally related to the fluoroquinolones. It is a type II DNA topoisomerase inhibitor and has broad-spectrum antibacterial activity against both Gram-positive and Gram-negative bacteria [1-3]. Note that structure shown here matches the PubChem standardized chemical structure. There are varying representations of its stereochemistry across other databases.

trovafloxacin is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 99.23
Molecular weight 416.35
XLogP 1.39
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES C1=C(C=C(C(=C1)N2C=C(C(=O)C3=C2N=C(C(=C3)F)N4C[C@H]5[C@@H](C4)C5N)C(=O)O)F)F
Isomeric SMILES C1[C@@H]2[C@@H](C2N)CN1C3=C(C=C4C(=O)C(=CN(C4=N3)C5=C(C=C(C=C5)F)F)C(=O)O)F
InChI InChI=1S/C20H15F3N4O3/c21-8-1-2-15(13(22)3-8)27-7-12(20(29)30)17(28)9-4-14(23)19(25-18(9)27)26-5-10-11(6-26)16(10)24/h1-4,7,10-11,16H,5-6,24H2,(H,29,30)/t10-,11+,16?
InChI Key WVPSKSLAZQPAKQ-SOSAQKQKSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes. FDA (1997)  |  EMA (1998)
Withdrawn drug? Yes
International Nonproprietary Names Click here for help
INN number INN
7370 trovafloxacin
Synonyms Click here for help
CP-99,219 | Trovan® | Turvel®
Database Links Click here for help
Specialist databases
Antibiotic DB Antibiotic DB Database logo Trovafloxacin
Other databases
GtoPdb PubChem SID 500839886
PubChem CID 62959
Search Google for chemical match using the InChIKey WVPSKSLAZQPAKQ-SOSAQKQKSA-N
Search Google for chemicals with the same backbone WVPSKSLAZQPAKQ
Search PubMed clinical trials trovafloxacin
Search PubMed titles trovafloxacin
Search PubMed titles/abstracts trovafloxacin
UniChem Compound Search for chemical match using the InChIKey WVPSKSLAZQPAKQ-SOSAQKQKSA-N
UniChem Connectivity Search for chemical match using the InChIKey WVPSKSLAZQPAKQ-SOSAQKQKSA-N
Wikipedia Trovafloxacin

Product suppliers

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Product supplier links are provided as a service to assist in identifying commercial suppliers of reagents that are mentioned on the IUPHAR/BPS Guide to PHARMACOLOGY database website, and do not imply their endorsement by NC-IUPHAR.

Links are provided in return for sponsorship, used to fund improvements to this database. The sponsorship account is managed and audited by the University of Edinburgh, a charitable body registered in Scotland, SC005336. If you are interested in sponsoring the database, please contact us.

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MedChemExpress
Trovafloxacin (links to external site)
Cat. No. HY-A0170
(Same CID)