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CK-586   Click here for help

GtoPdb Ligand ID: 13526

Synonyms: CK-4021586 | CK586 | compound 4 [WO2022187501A1]
Compound class: Synthetic organic
Comment: CK-586 (CK-4021586) is an oral cardiac myosin inhibitor [2]. It is one of the compounds claimed in Cytokinetics' patent WO2022187501A1 [1]. The name to structure was confirmed during the 'First Time disclosures' session at the ACS Spring 2025 meeting in San Diego.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 6
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 60.93
Molecular weight 405.44
XLogP 0.64
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES C[C@H]1CC[C@@H](CC1)N2CC(=O)N(CC3=CC=C(C(=C3)F)F)C4(CN(C4)C([H])=O)C2=O
Isomeric SMILES [H]C(=O)N1CC2(C1)N(CC3=CC=C(F)C(F)=C3)C(=O)CN([C@H]4CC[C@H](C)CC4)C2=O
InChI InChI=1S/C21H25F2N3O3/c1-14-2-5-16(6-3-14)25-10-19(28)26(9-15-4-7-17(22)18(23)8-15)21(20(25)29)11-24(12-21)13-27/h4,7-8,13-14,16H,2-3,5-6,9-12H2,1H3/t14-,16-
InChI Key HLMGUFOCTBBSLK-KOMQPUFPSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
No information available.
Summary of Clinical Use Click here for help
CK-586 is a clinical lead for the treatment of hypertrophic cardiomyopathy.
Clinical Trials
Clinical Trial ID Title Type Source Comment References
NCT05877053 A Single and Multiple Ascending Dose Study of CK-4021586 in Healthy Adult Participants Phase 1 Interventional Cytokinetics