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Synonyms: AZD-9150 | AZD9150 | ISIS STAT3Rx
Compound class:
Nucleic acid
Comment: Danvatirsen (AZD9150) is a phosphorothioate antisense oligonucleotide that was designed to inhibit expression of signal transducer and activator of transcription 3 (STAT3) as an anti-tumour mechanism [2-4]. It contains 2′-4′ constrained ethyl (cEt)-modified residues that increase affinity for target mRNA [2].
Full sequence as provided in the agent's INN record is: all-P-ambo-2'-O,4'-C-[(1S)-ethane-1,1-diyl]-5-methyl-P-thiocytidylyl-(3'→5')-2'-O,4'-C-[(1S)-ethane-1,1-diyl]-5-methyl-P-thiouridylyl-(3'→5')-2'-O,4'-C-[(1S)-ethane-1,1-diyl]-P-thioadenylyl-(3'→5')-P-thiothymidylyl-(3'→5')-P-thiothymidylyl-(3'→5')-P-thiothymidylyl-(3'→5')-2'-deoxy-P-thioguanylyl-(3'→5')-2'-deoxy-P-thioguanylyl-(3'→5')-2'-deoxy-P-thioadenylyl-(3'→5')-P-thiothymidylyl-(3'→5')-2'-deoxy-P-thioguanylyl-(3'→5')-P-thiothymidylyl-(3'→5')-2'-deoxy-5-methyl-P-thiocytidylyl-(3'→5')-2'-O,4'-C-[(1S)-ethane-1,1-diyl]-P-thioadenylyl-(3'→5')-2'-O,4'-C-[(1S)-ethane-1,1-diyl]-P-thioguanylyl-(3'→5')-2'-O,4'-C-[(1S)-ethane-1,1-diyl]-5-methylcytidine, but we have been unable to resolve this to a SMILES or HELM notation. |
Classification  |
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| Compound class | Nucleic acid |
| Compound subclass | Antisense oligonucleotide (ASO) |
| Target | STAT-3 mRNA 3'UTR |
| International Nonproprietary Names |
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| INN number | INN |
| 10612 | danvatirsen |
| Synonyms |
| AZD-9150 | AZD9150 | ISIS STAT3Rx |
| Database Links |
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| CAS Registry No. | 1402100-56-4 (source: WHO INN record) |
| ChEMBL Ligand | CHEMBL4297739 |
| DrugBank Ligand | DB14825 |
| GtoPdb PubChem SID | 504705426 |
| Search PubMed clinical trials | danvatirsen |
| Search PubMed titles | danvatirsen |
| Search PubMed titles/abstracts | danvatirsen |
