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sevasemten   Click here for help

GtoPdb Ligand ID: 13704

Synonyms: compound 6 [US11091464B2] | EDG-5506 | EDG5506
Compound class: Synthetic organic
Comment: Sevasemten (EDG-5506) is an oral small molecule that inhibits fast skeletal muscle myosin ATPase [1], with the intention of behaviour as a muscle stabiliser for the treatment of dystrophinopathies.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 7
Hydrogen bond donors 0
Rotatable bonds 6
Topological polar surface area 78.98
Molecular weight 381.29
XLogP 0.59
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES C1=CC(=O)N(CC2=CN=CC(=C2)F)N=C1C3=CN=C(N=C3)OCC(F)(F)F
Isomeric SMILES C1=CC(=O)N(N=C1C2=CN=C(N=C2)OCC(F)(F)F)CC3=CC(=CN=C3)F
InChI InChI=1S/C16H11F4N5O2/c17-12-3-10(4-21-7-12)8-25-14(26)2-1-13(24-25)11-5-22-15(23-6-11)27-9-16(18,19)20/h1-7H,8-9H2
InChI Key XFPJKQRXBAFXNK-UHFFFAOYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
No information available.
Summary of Clinical Use Click here for help
EDG-5506 is in clinical development as a potential treatment for muscular dystrophies, including Duchenne and Becker subtypes.
Clinical Trials
Clinical Trial ID Title Type Source Comment References
NCT05291091 Phase 2 Study of EDG-5506 in Becker Muscular Dystrophy (GRAND CANYON) Phase 2 Interventional Edgewise Therapeutics, Inc.
NCT05540860 A Study of EDG-5506 in Children With Duchenne Muscular Dystrophy (LYNX) Phase 2 Interventional Edgewise Therapeutics, Inc.
NCT06066580 Open-Label Extension of EDG-5506 in Participants With Becker Muscular Dystrophy Phase 2 Interventional Edgewise Therapeutics, Inc.
NCT06100887 Phase 2 Study of EDG-5506 in Children and Adolescents with Duchenne Muscular Dystrophy Previously Treated with Gene Therapy (FOX) Phase 2 Interventional Edgewise Therapeutics, Inc.