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AZD2389   Click here for help

GtoPdb Ligand ID: 13842

Synonyms: AZD-2389 | example 67 [WO2022130270A1]
Compound class: Synthetic organic
Comment: The chemical structure of AZD2389 was disclosed during the 'First Time disclosures' session at the ACS Spring 2025 meeting in San Diego [2]. This matches one of the compounds claimed in Astrazeneca's patent WO2022130270A1 [1]. AZD2389 is proposed to inhibit the prolyl endopeptidase activity of fibroblast activation protein (FAP; i.e. inhibition of cleavage of FGF21 and α2-antiplasmin/α2-AP), as a mechanism to treat liver fibrosis in metabolic dysfunction-associated steatohepatitis (MASH) where elevated FAP expression drives pathogenic hepatic fibroblasts.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 8
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 123.33
Molecular weight 411.48
XLogP -0.85
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES C1=CC2=NC=CC(=C2C=C1N3CCOCC3)C(=O)NCC(=O)N4CSC[C@H]4C#N
Isomeric SMILES O=C(CNC(=O)C1=C2C=C(C=CC2=NC=C1)N3CCOCC3)N4CSC[C@H]4C#N
InChI InChI=1S/C20H21N5O3S/c21-10-15-12-29-13-25(15)19(26)11-23-20(27)16-3-4-22-18-2-1-14(9-17(16)18)24-5-7-28-8-6-24/h1-4,9,15H,5-8,11-13H2,(H,23,27)/t15-/m1/s1
InChI Key GECJKRWOVGXGCO-OAHLLOKOSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
References
1. Branalt J, Holm B, Johansson M, Karlsson O, Knerr DL, Nordqvist A, Sheppard RJ, Swanson M, Tomberg A. (2022)
N-(2-(4-cyanothiazolidin-3-yl)-2-oxoethyl)- quinoline-4-carboxamides.
Patent number: WO2022130270A1. Assignee: Astrazeneca Ab. Priority date: 16/12/2021. Publication date: 23/06/2022.
2. Nordqvist A, Brånalt J, Winiwarter S, Petersen J, Eriksson AW, Liljeblad M, Janzén D, Miliotis T, Carlsson ET, Liu J et al.. 
AZD2389, a first in class candidate drug for the treatment of metabolic dysfunction-associated steatohepatitis.
Accessed on 03/04/2025. Modified on 03/04/2025. acs.digitellinc.com, https://acs.digitellinc.com/p/s/azd2389-a-first-in-class-candidate-drug-for-the-treatment-of-metabolic-dysfunction-associated-steatohepatitis-622940