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ORIC-114   Click here for help

GtoPdb Ligand ID: 13880

Synonyms: ORIC114
Compound class: Synthetic organic
Comment: ORIC-114 is an advanced, orally bioavailable, brain penetrant EGFR and ERBB2 (HER2) inhibitor that is designed to target these receptor tyrosine kinases with oncogenic exon 20 insertion mutations in metastatic non-small-cell lung cancer and other similarly mutated solid tumours [1].
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 10
Hydrogen bond donors 3
Rotatable bonds 11
Topological polar surface area 125.34
Molecular weight 674.74
XLogP 1.8
No. Lipinski's rules broken 1

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES C=CC(=O)NC1=CC(=C(C=C1N2CCC(CC2)N3CCN(CC3)C4CC4)C(=O)O)NC5=NC=NC(=C5)N6[C@H](CCO6)C7=CC(=CC(=C7)F)F
Isomeric SMILES C=CC(=O)NC1=C(C=C(C(=C1)NC2=CC(=NC=N2)N3[C@H](CCO3)C4=CC(=CC(=C4)F)F)C(=O)O)N5CCC(CC5)N6CCN(CC6)C7CC7
InChI InChI=1S/C35H40F2N8O4/c1-2-34(46)41-29-19-28(40-32-20-33(39-21-38-32)45-30(7-14-49-45)22-15-23(36)17-24(37)16-22)27(35(47)48)18-31(29)44-8-5-26(6-9-44)43-12-10-42(11-13-43)25-3-4-25/h2,15-21,25-26,30H,1,3-14H2,(H,41,46)(H,47,48)(H,38,39,40)/t30-/m1/s1
InChI Key MSIHWUDQPVKDLP-SSEXGKCCSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
5-[4-(4-cyclopropylpiperazin-1-yl)piperidin-1-yl]-2-[[6-[(3R)-3-(3,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-(prop-2-enoylamino)benzoic acid
Synonyms Click here for help
ORIC114
Database Links Click here for help
GtoPdb PubChem SID 513757565
PubChem CID 172991801
Search Google for chemical match using the InChIKey MSIHWUDQPVKDLP-SSEXGKCCSA-N
Search Google for chemicals with the same backbone MSIHWUDQPVKDLP
UniChem Compound Search for chemical match using the InChIKey MSIHWUDQPVKDLP-SSEXGKCCSA-N
UniChem Connectivity Search for chemical match using the InChIKey MSIHWUDQPVKDLP-SSEXGKCCSA-N