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lactisole   Click here for help

GtoPdb Ligand ID: 13900

Synonyms: (±)-lactisole | 2-PMP-PA
Compound class: Synthetic organic
Comment: Lactisole blocks activation of sweet receptor TAS1R2/TAS1R3 heterodimers, by binding to transmembrane domain 3 of the TAS1R3 subunit and disrupting G protein signalling [1-3]. This entry represents the racemic mixture of (R)- and (S)-isomers of lactisole. There is evidence that the (S)-isomer is the more potent negative modulator of receptor function [2].
Lactisole is used as a food additive, principally to suppress sweetness and enhance fruit flavours in highly sweet sugar-preserved fruit products (e.g. jams).
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 55.76
Molecular weight 196.2
XLogP 1.2
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES CC(C(=O)O)OC1=CC=C(C=C1)OC
Isomeric SMILES CC(C(=O)O)OC1=CC=C(C=C1)OC
InChI InChI=1S/C10H12O4/c1-7(10(11)12)14-9-5-3-8(13-2)4-6-9/h3-7H,1-2H3,(H,11,12)
InChI Key MIEKOFWWHVOKQX-UHFFFAOYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
References
1. Hao S, Guthrie B, Kim SK, Balanda S, Kubicek J, Murtaza B, Khan NA, Khakbaz P, Su J, Goddard 3rd WA. (2024)
Steviol rebaudiosides bind to four different sites of the human sweet taste receptor (T1R2/T1R3) complex explaining confusing experiments.
Commun Chem, 7 (1): 236. [PMID:39424933]
2. Nakagita T, Ishida A, Matsuya T, Kobayashi T, Narukawa M, Hirokawa T, Hashimoto M, Misaka T. (2019)
Structural insights into the differences among lactisole derivatives in inhibitory mechanisms against the human sweet taste receptor.
PLoS One, 14 (3): e0213552. [PMID:30883570]
3. Nakagita T, Matsuya T, Narukawa M, Kobayashi T, Hirokawa T, Misaka T. (2023)
Modeling the structure of the transmembrane domain of T1R3, a subunit of the sweet taste receptor, with neohesperidin dihydrochalcone using molecular dynamics simulation.
Biosci Biotechnol Biochem, 87 (12): 1470-1477. [PMID:37715303]