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sapablursen   Click here for help

GtoPdb Ligand ID: 13914

Synonyms: Ionis-tmprss6-lrx | ISIS 702843 | ISIS-702843 | ISIS702843
Compound class: Nucleic acid
Comment: Sapablursen (ISIS 702843) is a N-acetyl galactosamine (GalNAc3) modified antisense oligonucleotide that is designed to reduce production of transmembrane protease serine 6 messenger (TMPRSS6) protein [1], as a mechanism to elevate expression of hepcidin and stabilise iron homeostasis in hematologic diseases.
Primary nucleotide sequence is provided without annotation of base and bond modifications, or glycan conjugation.
Classification Click here for help
Compound class Nucleic acid
Compound subclass Antisense oligonucleotide (ASO)
Target TMPRSS6 mRNA
International Nonproprietary Names Click here for help
INN number INN
11518 sapablursen
Synonyms Click here for help
Ionis-tmprss6-lrx | ISIS 702843 | ISIS-702843 | ISIS702843
Database Links Click here for help
CAS Registry No. 2273007-95-5 (source: WHO INN record)
GtoPdb PubChem SID 513757599
Search PubMed clinical trials sapablursen
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