GtoPdb is requesting financial support from commercial users. Please see our sustainability page for more information.

APL-2301   Click here for help

GtoPdb Ligand ID: 13957

Synonyms: ASN-1733 | MET-102
Compound class: Synthetic organic
Comment: APL-2301 is a nitroxoline derivative with broad-spectrum antibacterial activity [2]. It is being developed to target infections caused by Acinetobacter baumannii.
2D Structure
Click here for help

2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

✖
Click here for structure editor
Physico-chemical Properties
Click here for help

Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

✖
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 75.73
Molecular weight 303.5
XLogP 2.99
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
Click here for help

SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

✖
Canonical SMILES C1=CN=C2C(=C1)C(=C(C(=C2O)[N+](=O)[O-])Br)Cl
Isomeric SMILES C1=CC2=C(C(=C(C(=C2Cl)Br)[N+](=O)[O-])O)N=C1
InChI InChI=1S/C9H4BrClN2O3/c10-5-6(11)4-2-1-3-12-7(4)9(14)8(5)13(15)16/h1-3,14H
InChI Key BZGYNSYRIWILNU-UHFFFAOYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
References
1. Asieris Pharmaceuticals. 
APL-2301, a FIC small molecule developed by Asieris for the treatment of Acinetobacter baumannii infection, was approved for Phase I clinical trials in Australia.
Accessed on 17/06/2025. Modified on 17/06/2025. https://asieris.com/apl-2301-a-compound-developed-by-asieris-for-the-treatment-of-acinetobacter-baumannii-infection-was-approved-for-phase-i-clinical-trials-in-australia/
2. He P, Huang S, Wang R, Yang Y, Yang S, Wang Y, Qi M, Li J, Liu X, Zhang X et al.. (2024)
Novel nitroxoline derivative combating resistant bacterial infections through outer membrane disruption and competitive NDM-1 inhibition.
Emerg Microbes Infect, 13 (1): 2294854. [PMID:38085067]