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SBI-553   Click here for help

GtoPdb Ligand ID: 14260

Synonyms: compound 18 [PMID: 31390201] | SBI553
PDB Ligand
Compound class: Synthetic organic
Comment: SBI-553 is reported as a biased allosteric modulator of the neurotensin receptor 1 (NTS1; NTSR1) [1-2]. It binds to the intracellular GPCR-transducer interface and biases neurotensin-NTS1 signalling away from Gq/11 and towards alternative G protein activation.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 60.66
Molecular weight 450.55
XLogP 2.53
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES CN(CCO)C1=CC=C2C(=C1)C(=NC(=N2)C3(CC3)F)N4CCC(CC4)C5=C(C=CC=C5)OC
Isomeric SMILES CN(CCO)C1=CC2=C(C=C1)N=C(N=C2N3CCC(CC3)C4=CC=CC=C4OC)C5(CC5)F
InChI InChI=1S/C26H31FN4O2/c1-30(15-16-32)19-7-8-22-21(17-19)24(29-25(28-22)26(27)11-12-26)31-13-9-18(10-14-31)20-5-3-4-6-23(20)33-2/h3-8,17-18,32H,9-16H2,1-2H3
InChI Key BLWXTJQMEBQCIZ-UHFFFAOYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
2-[[2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazolin-6-yl]-methylamino]ethanol
Synonyms Click here for help
compound 18 [PMID: 31390201] | SBI553
Database Links Click here for help
BindingDB Ligand 297513
CAS Registry No. 1849603-72-0 (source: PubChem)
ChEMBL Ligand CHEMBL4576388
GtoPdb PubChem SID 521588900
PubChem CID 118610427
RCSB PDB Ligand SRW
Search Google for chemical match using the InChIKey BLWXTJQMEBQCIZ-UHFFFAOYSA-N
Search Google for chemicals with the same backbone BLWXTJQMEBQCIZ
UniChem Compound Search for chemical match using the InChIKey BLWXTJQMEBQCIZ-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey BLWXTJQMEBQCIZ-UHFFFAOYSA-N