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zalunfiban   Click here for help

GtoPdb Ligand ID: 14275

Synonyms: compound 13 [PMID: 24461295] | RUC-4 | RUC4
Compound class: Synthetic organic
Comment: Zalunfiban (RUC-4; CeleCor Therapeutics) is a integrin αIIbβ3 (glycoprotein IIb/IIIa) inhibitor/antagonist [1,4,7]. It binds to the β3 subunit's metal ion-dependent adhesion site (MIDAS) but does not alter the protein conformation [2].
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 10
Hydrogen bond donors 3
Rotatable bonds 5
Topological polar surface area 153.08
Molecular weight 386.43
XLogP -1.82
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES C1CN(CCN1)C2=CC(=O)N3C(=N2)SC(=N3)C4=CN=CC(=C4)NC(=O)CN
Isomeric SMILES C1CN(CCN1)C2=CC(=O)N3C(=N2)SC(=N3)C4=CC(=CN=C4)NC(=O)CN
InChI InChI=1S/C16H18N8O2S/c17-7-13(25)20-11-5-10(8-19-9-11)15-22-24-14(26)6-12(21-16(24)27-15)23-3-1-18-2-4-23/h5-6,8-9,18H,1-4,7,17H2,(H,20,25)
InChI Key LTVKZVGAALCRFW-UHFFFAOYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
No information available.
Summary of Clinical Use Click here for help
Zalunfiban (RUC-4) acts as a rapid but transient antiplatelet/antithrombotic agent, and is designed for single-dose subcutaneous administration to patients suspected with ST-segment elevation myocardial infarction (STEMI) at first medical contact (including pre-hospital admission and pre-coronary intervention) [1,4,7].
Clinical Trials
Clinical Trial ID Title Type Source Comment References
NCT04825743 A Phase 3 Study of Zalunfiban in Subjects With ST-elevation MI Phase 3 Interventional CeleCor Therapeutics The CeleBrate trial 5-6
NCT04284995 A Phase 2 Open Label Study to Assess the PK/PD Properties of RUC-4 in Patients With a ST-elevation Myocardial Infarction Phase 2 Interventional CeleCor Therapeutics
NCT03844191 A Randomized Phase 1 Dose-Escalation Study of Subcutaneously(SC) Administered RUC-4 Phase 1 Interventional CeleCor Therapeutics 3