GtoPdb is requesting financial support from commercial users. Please see our sustainability page for more information.

etripamil   Click here for help

GtoPdb Ligand ID: 14304

Synonyms: Cardamyst® | MSP-2017 | MSP2017
Approved drug
etripamil is an approved drug
Compound class: Synthetic organic
Comment: Etripamil (MSP-2017) acts as a fast-acting, short half-life L-type calcium-channel antagonist [1-2]. It is a structural analogue of verapamil.
2D Structure
Click here for help

2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

✖
Click here for structure editor
Physico-chemical Properties
Click here for help

Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

✖
Hydrogen bond acceptors 6
Hydrogen bond donors 0
Rotatable bonds 13
Topological polar surface area 71.79
Molecular weight 452.59
XLogP 3.56
No. Lipinski's rules broken 1

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
Click here for help

SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

✖
Canonical SMILES CC(C)[C@](CCCN(C)CCC1=CC=CC(=C1)C(=O)OC)(C#N)C2=CC=C(C(=C2)OC)OC
Isomeric SMILES CC(C)[C@](CCCN(C)CCC1=CC(=CC=C1)C(=O)OC)(C#N)C2=CC(=C(C=C2)OC)OC
InChI InChI=1S/C27H36N2O4/c1-20(2)27(19-28,23-11-12-24(31-4)25(18-23)32-5)14-8-15-29(3)16-13-21-9-7-10-22(17-21)26(30)33-6/h7,9-12,17-18,20H,8,13-16H2,1-6H3/t27-/m0/s1
InChI Key VAZNEHLGJGSQEL-MHZLTWQESA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes. US FDA (2025)
IUPAC Name Click here for help
methyl 3-[2-[[(4S)-4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl]-methylamino]ethyl]benzoate
International Nonproprietary Names Click here for help
INN number INN
10134 etripamil
Synonyms Click here for help
Cardamyst® | MSP-2017 | MSP2017
Database Links Click here for help
CAS Registry No. 1593673-23-4 (source: WHO INN record)
ChEMBL Ligand CHEMBL3707312
DrugBank Ligand DB12605
PubChem CID 91824132
Search Google for chemical match using the InChIKey VAZNEHLGJGSQEL-MHZLTWQESA-N
Search Google for chemicals with the same backbone VAZNEHLGJGSQEL
Search PubMed clinical trials etripamil
Search PubMed titles etripamil
Search PubMed titles/abstracts etripamil
UniChem Compound Search for chemical match using the InChIKey VAZNEHLGJGSQEL-MHZLTWQESA-N
UniChem Connectivity Search for chemical match using the InChIKey VAZNEHLGJGSQEL-MHZLTWQESA-N