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MP-16   Click here for help

GtoPdb Ligand ID: 14310

Compound class: Synthetic organic
Comment: MP-16 is a c-Myc-PROTAC [1]. It includes a double-stranded nucleotide to engage the c-MYC protein and the small molecule VH032 (attached to the 5' end of the reverse strand via a short linker) that binds to the VHL E3 ubiquitin ligase. The construct induces formation of a VHL/PROTAC/c-Myc ternary complex that leads to selective VHL-mediated proteosomal degradation of c-MYC.
The full chemical SMILES is not available.
Classification Click here for help
Compound class Synthetic organic
Ligand families/groups PROTACs, molecular glues and other degraders