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Compound class:
Synthetic organic
Comment: MP-16 is a c-Myc-PROTAC [1]. It includes a double-stranded nucleotide to engage the c-MYC protein and the small molecule VH032 (attached to the 5' end of the reverse strand via a short linker) that binds to the VHL E3 ubiquitin ligase. The construct induces formation of a VHL/PROTAC/c-Myc ternary complex that leads to selective VHL-mediated proteosomal degradation of c-MYC.
The full chemical SMILES is not available. |
| Bioactivity Comments |
| MP-16 degrades c-MYC in HCC cell lines, with maximum degradation evident between 4-8 hours after exposure [1]. This effect translates to anti-tumour activity in these cell lines. |
| Selectivity at other protein targets | ||||||||||||||||||||||||||||||||||
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