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MP-16   Click here for help

GtoPdb Ligand ID: 14310

Compound class: Synthetic organic
Comment: MP-16 is a c-Myc-PROTAC [1]. It includes a double-stranded nucleotide to engage the c-MYC protein and the small molecule VH032 (attached to the 5' end of the reverse strand via a short linker) that binds to the VHL E3 ubiquitin ligase. The construct induces formation of a VHL/PROTAC/c-Myc ternary complex that leads to selective VHL-mediated proteosomal degradation of c-MYC.
The full chemical SMILES is not available.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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References
1. Ai M, Ma H, He J, Xu F, Ming Y, Ye Z, Zheng Q, Luo D, Yang K, Li J et al.. (2024)
Targeting oncogenic transcriptional factor c-myc by oligonucleotide PROTAC for the treatment of hepatocellular carcinoma.
Eur J Med Chem, 280: 116978. [PMID:39447458]