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povetacicept   Click here for help

GtoPdb Ligand ID: 14426

Synonyms: ALPN-303 | TACI vTD-Fc
Immunopharmacology Ligand
Compound class: Peptide
Comment: Povetacicept (ALPN-303) is a Fc fusion protein that contains a variant TACI domain of the TNFRSF13B receptor for the peptide cytokines B cell activating factor (BAFF; TNFSF13B) and a proliferation-inducing ligand (APRIL; TNFSF13) [2]. It functionally antagonises the cellular signalling pathways of these ligands via TNFRSF13B on B cells.
In the peptide sequence provided the TACI domain is amino acids 1-43, with a short linker (GSGGGGS 44-50 ) and the remainder being the Fc domain. The functional peptide is a dimer, linked by inter-chain disulphide bridges.
Selectivity at ligand targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
APRIL Hs Fusion protein Binding 12.0 pKd -
⤷ pKd 12.0 (Kd 1x10-12 M)
BAFF Hs Fusion protein Binding 10.2 pKd - 2
⤷ pKd 10.2 (Kd 5.93x10-11 M) [2]