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μ-conotoxin KIIIA   Click here for help

GtoPdb Ligand ID: 14461

Synonyms: μ-KIIIA | mu-KIIIA
Compound class: Peptide
Comment: μ-conotoxin KIIIA is an analgesic neuropeptide produced by Conus kinoshitai (Kinoshita's cone seasnail). It acts via blockade of mammalian neuronal voltage-gated sodium channels (NaV) [1-2].
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Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Nav1.2 Rn Channel blocker Inhibition 8.3 pKd - 2
pKd 8.3 (Kd 5x10-9 M) [2]
Nav1.4 Rn Channel blocker Binding 7.3 pKd - 2
pKd 7.3 (Kd 5x10-8 M) [2]
Nav1.1 Rn Channel blocker Binding 6.5 pKd - 2
pKd 6.5 (Kd 2.9x10-7 M) [2]
Nav1.7 Rn Channel blocker Binding 6.5 pKd - 2
pKd 6.5 (Kd 2.9x10-7 M) [2]