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AMX-883   Click here for help

GtoPdb Ligand ID: 14488

Synonyms: AMX883
Compound class: Synthetic organic
Comment: AMX-883 is an orally bioavailable, reversibly covalent, DCAF16 E3 ligase-mediated, BRD9 glue degrader [3]. It was designed to promote maturation and reduce survival of acute myeloid leukaemia (AML) blasts as a therapeutic mechanism. AMX-883 is a structural derivative of the disclosed BRD9-selective degrader AMPTX1 [1-2].
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 9
Hydrogen bond donors 0
Rotatable bonds 13
Topological polar surface area 95.34
Molecular weight 766.98
XLogP 4.65
No. Lipinski's rules broken 2

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES CC(C)[C@@H]1C2=CC(=CC(=C2CCN1C(=O)/C(=C/C(C)(C)CF)/C#N)CN3CCN(CC4=C(C=C(C=C4OC)C5=CC(C)C(=O)C(=C5C)C)OC)CC63CC6)OC
Isomeric SMILES COC1=CC2=C(CCN([C@@H]2C(C)C)C(=O)\C(=C\C(C)(C)CF)\C#N)C(CN3CCN(CC4=C(OC)C=C(C=C4OC)C5=CC(C)C(=O)C(C)=C5C)CC36CC6)=C1
InChI InChI=1S/C46H59FN4O5/c1-28(2)42-38-21-35(54-8)18-33(36(38)11-14-51(42)44(53)34(23-48)22-45(6,7)26-47)24-50-16-15-49(27-46(50)12-13-46)25-39-40(55-9)19-32(20-41(39)56-10)37-17-29(3)43(52)31(5)30(37)4/h17-22,28-29,42H,11-16,24-27H2,1-10H3/b34-22+/t29?,42-/m1/s1
InChI Key SHEVQYBIVIKOPV-CUWJCDLUSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
References
1. Hughes SJ, Stec WJ, Davies CTR, McGarry D, Williams A, Carrara M, Del Barco Barrantes I, Harris R, Tasegian A, Owens DDG et al.. (2025)
Mode of action of a DCAF16-recruiting targeted glue that can selectively degrade BRD9.
Nat Commun, 16 (1): 8516. [PMID:41145412]
2. Hughes SJ, Stec WJ, Davies CTR, McGarry D, Williams A, Del Barco Barrantes I, Harris R, Owens DDG, Fawcett A, Hellicar J et al.. (2025)
Selective degradation of BRD9 by a DCAF16-recruiting targeted glue: mode of action elucidation and in vivo proof of concept.
biorxiv, Preprint. DOI: 10.1101/2024.12.31.630899
3. O'Rourke M, Modis L, Harris R, Tasegian A, Azevedo A, Del Barco Barrantes I, Greger L, Gokhale P, Lock R, Connerty P et al.. (2025)
Amx-883, a potent and selective degrader of BRD9 drives differentiation in acute myeloid leukaemia and shows synergistic efficacy in combination with venetoclax In Vivo and prevents the emergence of resistance to venetoclax in vitro.
Blood, 146 (Supplement 1): 1489. DOI: 10.1182/blood-2025-1489