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TRI-611   Click here for help

GtoPdb Ligand ID: 14491

Synonyms: Compound 1 [US20260042752] | TRI611
Compound class: Synthetic organic
Comment: TRI-611 (TRIANA Biomedicines) is a CNS-penetrant, CRBN-mediated molecular glue degrader of ALK receptor tyrosine kinase (ALK) [1]. As the ligand engages an allosteric site it is able to drive ubiquitination and degradation of abnormal ALK proteins, including clinically relevant variants that confer resistance to existing tyrosine kinase inhibitors, and in tumours with ALK oncogenic fusions.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Click here for structure editor
Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 109.66
Molecular weight 404.38
XLogP 0.89
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES C1=CC=C(C=C1)C2=NOC(=N2)CC3=CC=C4C(=C3)N(C5CCC(=O)NC5=O)C(=O)O4
Isomeric SMILES O=C1OC2=C(C=C(CC3=NC(=NO3)C4=CC=CC=C4)C=C2)N1C5CCC(=O)NC5=O
InChI InChI=1S/C21H16N4O5/c26-17-9-7-14(20(27)22-17)25-15-10-12(6-8-16(15)29-21(25)28)11-18-23-19(24-30-18)13-4-2-1-3-5-13/h1-6,8,10,14H,7,9,11H2,(H,22,26,27)
InChI Key XGNIJIQFXVUHJG-UHFFFAOYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
No information available.
Summary of Clinical Use Click here for help
TRI-611 was progressed as an oncology clinical candidate, principally for ALK-mutant NSCLC.
Clinical Trials
Clinical Trial ID Title Type Source Comment References
NCT07491497 A Phase 1/2 Study of TRI-611 in ALK-Positive NSCLC Phase 1/Phase 2 Interventional TRIANA Biomedicines, Inc.