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bronopol   Click here for help

GtoPdb Ligand ID: 14530

Compound class: Synthetic organic
Comment: Bronopol is a broad-spectrum antimicrobial compound used as a preservative in pharmaceuticals, cosmetics, and industrial products [2]. Bronopol and the related compound bronidox (PubChem CID 1807) inhibit bacterial biofilm formation [3].
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 83.6
Molecular weight 199.99
XLogP -0.7
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES C(C(CO)(Br)[N+](=O)[O-])O
Isomeric SMILES C(C(CO)([N+](=O)[O-])Br)O
InChI InChI=1S/C3H6BrNO4/c4-3(1-6,2-7)5(8)9/h6-7H,1-2H2
InChI Key LVDKZNITIUWNER-UHFFFAOYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
References
1. Bryce DM, Croshaw B, Hail JE, Holland VR, Lessel B (1978). 
The activity and safety of the antimicrobial agent bronopol (2-bromo-2-nitropropan-1,3-diol).
Accessed on 29/05/2026. Modified on 29/05/2026. J. Soc. Cosmet. Chem. 29: 3-24, https://library.scconline.org/v029n01/1
2. Croshaw B, Groves MJ, Lessel B. (1964)
Some properties of bronopol, a new antimicrobial agent active against Pseudomonas aeruginosa.
J Pharm Pharmacol, 16: SUPPL:127-30T. [PMID:14265925]
3. Lee VE, O'Neill AJ. (2019)
Potential for repurposing the personal care product preservatives bronopol and bronidox as broad-spectrum antibiofilm agents for topical application.
J Antimicrob Chemother, 74 (4): 907-911. [PMID:30590494]