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BB-83698   Click here for help

GtoPdb Ligand ID: 14538

Synonyms: forazemin | FP530
Compound class: Synthetic organic
Comment: BB-83698 is an orally bioavailable antibacterial that inhibits peptide deformylase (PDF), a bacterial enzyme essential for protein maturation [3].
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 13
Topological polar surface area 111.65
Molecular weight 530.66
XLogP 2.13
No. Lipinski's rules broken 1

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES CC(C)(C)[C@@H](C(=O)N1CCN(CC1)CC2=CC=C3C(=C2)OCO3)NC(=O)[C@H](CC4CCCC4)CN(C=O)O
Isomeric SMILES CC(C)(C)[C@@H](C(=O)N1CCN(CC1)CC2=CC3=C(C=C2)OCO3)NC(=O)[C@H](CC4CCCC4)CN(C=O)O
InChI InChI=1S/C28H42N4O6/c1-28(2,3)25(29-26(34)22(17-32(36)18-33)14-20-6-4-5-7-20)27(35)31-12-10-30(11-13-31)16-21-8-9-23-24(15-21)38-19-37-23/h8-9,15,18,20,22,25,36H,4-7,10-14,16-17,19H2,1-3H3,(H,29,34)/t22-,25-/m1/s1
InChI Key IBEANEPZNLVRRY-RCZVLFRGSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
References
1. Lewis K, Patil P, Liang HW, Astley E, Taher R, Lee MH, Norment D, Iinishi A, Gupta N, Sobolevskaia K et al.. (2026)
A deformylase inhibitor expands therapeutic options for Lyme disease.
Res Sq, Preprint. [PMID:42147198]
2. Ramanathan-Girish S, McColm J, Clements JM, Taupin P, Barrowcliffe S, Hevizi J, Safrin S, Moore C, Patou G, Moser H et al.. (2004)
Pharmacokinetics in animals and humans of a first-in-class peptide deformylase inhibitor.
Antimicrob Agents Chemother, 48 (12): 4835-42. [PMID:15561864]
3. Wise R, Andrews JM, Ashby J. (2002)
In vitro activities of peptide deformylase inhibitors against gram-positive pathogens.
Antimicrob Agents Chemother, 46 (4): 1117-8. [PMID:11897602]