Compound class:
Natural product or derivative
Comment: Molecular docking studies show interactions with 5-HT1A and 5-HT2A receptors [1]. In vivo reductions in depressive and anxiety symptoms have been demonstrated in rodents.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Amin F, Ibrahim MAA, Rizwan-Ul-Hasan S, Khaliq S, Gabr GA, Muhammad, Khan A, Sidhom PA, Tikmani P, Shawky AM et al.. (2022)
Interactions of Apigenin and Safranal with the 5HT1A and 5HT2A Receptors and Behavioral Effects in Depression and Anxiety: A Molecular Docking, Lipid-Mediated Molecular Dynamics, and In Vivo Analysis. Molecules, 27 (24). [PMID:36557792] |
2. Verkman AS, Galietta LJ. (2009)
Chloride channels as drug targets. Nat Rev Drug Discov, 8 (2): 153-71. [PMID:19153558] |