Abbreviated name: DCA
Synonyms: dichloroacetic acid
Compound class:
Synthetic organic
Comment: Dichloroacetate (DCA) is an orally available small molecule pyruvate dehydrogenase kinase inhibitor [4]. It acts as a metabolic regulator and has anti-cancer potential by promoting glucose oxidation over glycolysis, glycolysis being the metabolic pathway (Warburg effect) utilised by most cancer cells to resist apoptosis and gain proliferative advantage [1-3].
ChEMBL represents this compound without the charge (see link above). |
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References |
1. James MO, Jahn SC, Zhong G, Smeltz MG, Hu Z, Stacpoole PW. (2017)
Therapeutic applications of dichloroacetate and the role of glutathione transferase zeta-1. Pharmacol Ther, 170: 166-180. [PMID:27771434] |
2. Kankotia S, Stacpoole PW. (2014)
Dichloroacetate and cancer: new home for an orphan drug?. Biochim Biophys Acta, 1846 (2): 617-29. [PMID:25157892] |
3. Michelakis ED, Webster L, Mackey JR. (2008)
Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer. Br J Cancer, 99 (7): 989-94. [PMID:18766181] |
4. Sutendra G, Michelakis ED. (2013)
Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology. Front Oncol, 3: 38. [PMID:23471124] |