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Synonyms: EYEOO1 | Macugen® | NX183 | pegaptanib sodium
pegaptanib is an approved drug (FDA (2004), EMA (2006))
Compound class:
Nucleic acid
Comment: Pegaptanib is a RNA oligonucleotide aptamer that acts as a vascular endothelial growth factor A antagonist, anti-angiogenic agent.
It is a 28-mer RNA oligonucleotide that is covalently linked to two branched 20-kD polyethylene glycol (PEG) chains. Pegaptanib binds to the 165 isoform of VEGFA. It is formulated as a sodium adduct. The basic nucleotide sequence has modified nucleotides and a 5' pentylamino linker that acts as the PEG anchor. |
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Similar Ligands  |
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