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pegaptanib   Click here for help

GtoPdb Ligand ID: 6836

Synonyms: EYEOO1 | Macugen® | NX183 | pegaptanib sodium
Approved drug
pegaptanib is an approved drug (FDA (2004), EMA (2006))
Compound class: Nucleic acid
Comment: Pegaptanib is a RNA oligonucleotide aptamer that acts as a vascular endothelial growth factor A antagonist, anti-angiogenic agent.
It is a 28-mer RNA oligonucleotide that is covalently linked to two branched 20-kD polyethylene glycol (PEG) chains. Pegaptanib binds to the 165 isoform of VEGFA. It is formulated as a sodium adduct.
The basic nucleotide sequence has modified nucleotides and a 5' pentylamino linker that acts as the PEG anchor.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Nucleic Acid Sequence Click here for help
(5'-3')CGGAAUCAGUGAAUGCUUAUACAUCCGT