glucarpidase   Click here for help

GtoPdb Ligand ID: 7450

Synonyms: Voraxaze®
Approved drug
glucarpidase is an approved drug (FDA (2012), EMA (2022))
Compound class: Peptide
Comment: Glucarpidase, a recombinant form of the bacterial enzyme carboxypeptidase G2 (cpg2). Pseudomonas sp cpg2 has UniProt id P06621.
References
1. Green JM. (2012)
Glucarpidase to combat toxic levels of methotrexate in patients.
Ther Clin Risk Manag, 8: 403-13. [PMID:23209370]
2. Tuffaha HW, Al Omar S. (2012)
Glucarpidase for the treatment of life-threatening methotrexate overdose.
Drugs Today, 48 (11): 705-11. [PMID:23170306]