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Synonyms: Krystexxa® | puricase
pegloticase is an approved drug (FDA (2010), EMA (2013))
Compound class:
Peptide
Comment: Pegloticase is a porcine-like recombinant uricase, which is PEGylated to increase its biological half-life. The peptide sequence for the enzyme monomer is available in the ChEMBL entry. The enzyme is a tetramer, and lysine residues are PEGylated.
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| No information available. |
Summary of Clinical Use  |
| Used to treat chronic gout. |
| Mechanism Of Action and Pharmacodynamic Effects |
| The uricase activity of the drug converts uric acid to allantoin. Allantoin is more soluble than uric acid and is less likely to crystallise. |
| External links |
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For extended ADME data see the following: Drugs.com European Medicines Agency (EMA) |
