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Synonyms: MORAb-009
Compound class:
Antibody
Comment: Amatuximab is a chimeric monoclonal antibody to mesothelin (MSLN; Q13421), a cell surface glycoprotein highly expressed in malignant pleural mesothelioma, all pancreatic adenocarcinoma, the majority of ovarian adenocarcinoma, as well as in non-small cell lung and colorectal cancers[5].
The crystal structure of the Fab fragment of amatuximab in complex with a mesothelin fragment (amino acids 7-64) has been deposited in Protein Data Bank with accession 4F33 [4]. |
| Bioactivity Comments |
| Amatuximab binds human mesothelin with a Kd value of 1.5nM [2]. |
