Synonyms: Org 27569
Compound class:
Synthetic organic
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Fay JF, Farrens DL. (2012)
A key agonist-induced conformational change in the cannabinoid receptor CB1 is blocked by the allosteric ligand Org 27569. J Biol Chem, 287 (40): 33873-82. [PMID:22846992] |
2. Piscitelli F, Ligresti A, La Regina G, Coluccia A, Morera L, Allarà M, Novellino E, Di Marzo V, Silvestri R. (2012)
Indole-2-carboxamides as allosteric modulators of the cannabinoid CB₁ receptor. J Med Chem, 55 (11): 5627-31. [PMID:22571451] |
3. Price MR, Baillie GL, Thomas A, Stevenson LA, Easson M, Goodwin R, McLean A, McIntosh L, Goodwin G, Walker G et al.. (2005)
Allosteric modulation of the cannabinoid CB1 receptor. Mol Pharmacol, 68 (5): 1484-95. [PMID:16113085] |