imexon   Click here for help

GtoPdb Ligand ID: 8273

Synonyms: Amplimexon® (proposed trade name) | BM 06002 | BM-06002
Compound class: Synthetic organic
Comment: Imexon is a cyclizised 2-cyanoaziridine compound being investigated as an antitumour agent [4-5]. 2-cyanoaziridine compounds bind thiols such as cysteine, depleting them and allowing the accumulation of reactive oxygen species. This effect activates antioxidant gene expression, signifying induction of an oxidative stress response [1] and leads to irreversible cell damage and apoptosis.

imexon is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 0
Topological polar surface area 58.46
Molecular weight 111.04
XLogP -1.36
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES NC1=NC(=O)N2C1C2
Isomeric SMILES NC1=NC(=O)N2C1C2
InChI InChI=1S/C4H5N3O/c5-3-2-1-7(2)4(8)6-3/h2H,1H2,(H2,5,6,8)
InChI Key BIXBBIPTYBJTRY-UHFFFAOYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
4-amino-1,3-diazabicyclo[3.1.0]hex-3-en-2-one
International Nonproprietary Names Click here for help
INN number INN
4134 imexon
Synonyms Click here for help
Amplimexon® (proposed trade name) | BM 06002 | BM-06002
Database Links Click here for help
CAS Registry No. 59643-91-3
ChEMBL Ligand CHEMBL146428
DrugBank Ligand DB05003
GtoPdb PubChem SID 252166485
PubChem CID 68791
Search Google for chemical match using the InChIKey BIXBBIPTYBJTRY-UHFFFAOYSA-N
Search Google for chemicals with the same backbone BIXBBIPTYBJTRY
Search PubMed clinical trials imexon
Search PubMed titles imexon
Search PubMed titles/abstracts imexon
UniChem Compound Search for chemical match using the InChIKey BIXBBIPTYBJTRY-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey BIXBBIPTYBJTRY-UHFFFAOYSA-N
Wikipedia Imexon

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MedChemExpress
Imexon (links to external site)
Cat. No. HY-15385
(Same InChi Key)