Synonyms: SMP-114
Compound class:
Synthetic organic
Comment: Rimacalib (SMP-114) is an isoxazole derivative inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII) [2], CAMKII being an established pharmacological target for chronic inflammatory pain [1], as well as being involved in modulating synaptic plasticity and learning and memory processes.
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Immunopharmacology Comments |
CAMKII is an established pharmacological target for chronic inflammatory pain [1], with pharmacological inhibitors like rimacalib in development. |