Synonyms: LY-3303560 | LY3303560
Compound class:
Antibody
Comment: LY3303560 is a monoclonal antibody that selectively targets tau protein aggregates [1]. It is being developed by Eli Lilly for potential to treat Alzheimer's disease. The primary epitope for LY3303560 is located in the N-terminal region of tau.
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Bioactivity Comments |
LY3303560 binding affinity (KD) for tau monomer is 235 nM which is approximately 100-fold lower than its affinity for soluble tau aggregate [1]. LY3303560 demonstrated acceptable pharmacokinetic properties in rat and monkey. |
Other ligands which bind to or alter the activity of this ligand | ||||||||||||||||||||||||||||||||||||||||||||||
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