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Synonyms: AZD1061 | COV2-2130 | Evusheld® (tixagevimab + cilgavimab)
cilgavimab is an approved drug (EMA (2022))
Compound class:
Antibody
Comment: Cilgavimab is a monoclonal antibody against the surface spike protein of SARS-CoV-2 [3]. It was developed by AstraZeneca. This mAb blocks spike binding to ACE2 and prevents infection in animals. It is designed to be a long-acting agent, and in combination with tixagevimab (co-packaged combination= Evusheld®), is proposed as a therapeutic for those people who are likely to respond poorly to SARS-CoV-2 vaccines, or who cannot be vaccinated for any reason, including those who are immunocompromised [1]. Data from the Phase 3 PROVENT trial (NCT04625725) show protection from infection that lasts for at least six months. AstraZeneca have reported that Evusheld® retains neutralising activity against the BA.1 omicron (B.1.1.529) SARS-CoV-2 variant. Cilgavimab as a single agent rmore effectively neutralises the BA.2 omicron subvariant than tixagevimab in vitro [2], so the combination retains neutralising activity.
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| Bioactivity Comments |
| Binds to the trimeric S2Pecto synthetic spike protein mimic with an EC50 of 1.5 ng/ml [3]. |
| Selectivity at other protein targets | ||||||||||||||||||||||||||||||||||
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