hCG   Click here for help

GtoPdb Ligand ID: 1160

Synonyms: CG | human chorionic gonadotropin
Compound class: Endogenous peptide in human, mouse or rat
Comment: hCG is a heterodimeric protein, consisting of an α subunit (CGA; that it shares with LH, FSH and TSH) and a unique β subunit (CGB3).
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

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View more information in the IUPHAR Pharmacology Education Project: hcg

Natural/Endogenous Targets
Target
LH receptor
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
LH receptor Ligand is endogenous in the given species Hs Agonist Full agonist 9.9 – 11.8 pKd - 1-2
⤷ pKd 9.9 – 11.8 [1-2]
Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference
Potency order of endogenous ligands at LH receptor LH (CGA, LHB, P01215, P01229), hCG (CGA, CGB3, P01215, P01233) 1-2
Ligand mentioned in the following text fields
Glycoprotein hormone receptors overview