tisotumab vedotin   Click here for help

GtoPdb Ligand ID: 11719

Synonyms: HuMax-TF-ADC | TF-011-MMAE | tisotumab vedotin-tftv | Tivdak®
Approved drug
tisotumab vedotin is an approved drug (FDA (2021))
Compound class: Antibody
Comment: Tisotumab vedotin is an antibody-drug conjugate (ADC) of an anti-factor 3 monoclonal antibody that is conjugated to the antineoplastic agent monomethyl auristatin E (MMAE; PubChem CID 11542188) [1]. Tisotumab vedotin causes adverse events that are associated with disrupted coagulation [4].
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
coagulation factor III, tissue factor Primary target of this compound Hs Antibody Binding - - - 1