galegenimab   Click here for help

GtoPdb Ligand ID: 11759

Synonyms: 15H6v4.D221 | FHTR2163 | RG-6147 | RG6147 | RO-7171009 | RO7171009
Compound class: Antibody
Comment: Galegenimab is the INN that has been assigned to Genentech's anti-HTRA1 (HtrA serine peptidase 1) Fab antibody [6]. The antibody and its use are claimed in patent WO2017075212A1 [3]. HTRA1 is a serine protease whose substrates include transforming growth factor β [1,5], fibronectin, amyloid precursor protein [2] and Dickkop-related protein 3 (DKK3) [4]. Genetic polymorphisms in the HTRA1 gene are associated with an increased risk of developing neovascular age-related macular degeneration (and geographic atrophy) and with disease progression. Thus inhibition of HTRA1 proteolytic activity is being investigated for this ocular indication.
Click here for help
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
HtrA serine peptidase 1 Hs Antibody Inhibition 9.2 pKd - 3
pKd 9.2 (Kd 5.88x10-10 M) [3]