sotevtamab   Click here for help

GtoPdb Ligand ID: 11763

Synonyms: 16B5 [1] | AB-16B5 | AB-sCLU mAb | AB16B5
Compound class: Antibody
Comment: Sotevtamab (AB-16B5) is a humanized IgG2 antibody against secreted clusterin. It was developed by Alethia Biotherapeutics for anti-cancer potential. Peptide sequences of the heavy and light chains of the antibody are claimed in patent WO2011063523A1 [1], via which sotevtamab can be linked to the antibody designated as humanised 16B5. Sotevtamab is expected to inhibit clusterin-induced epithelial to mesenchymal transition, as a mechanism to both reduce tumour invasion and augment the response to standard of care chemotherapy.
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Selectivity at other protein targets
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
clusterin Hs Antibody Binding 8.4 pKd - 1
pKd 8.4 (Kd 4.49x10-9 M) [1]