pabinafusp alfa   Click here for help

GtoPdb Ligand ID: 11772

Synonyms: IZCARGO® | JR-141 | JR141
Approved drug
pabinafusp alfa is an approved drug (Japan (2021))
Compound class: Antibody
Comment: Pabinafusp (JR-141) is a fusion protein of the Fab domains of an anti-transferrin receptor monoclonal and the enzyme iduronate 2-sulfatase (IDS; P22304) [5], an enzyme that is deficient in patients with the lysosomal storage disease mucopolysaccharidosis type II (MPS II; Hunter syndrome) [1-2]. It is an intravenously administered enzyme replacement therapy. The anti-transferrin receptor component facilitates receptor-mediated movement of the fused enzyme across the blood-brain barrier [4].
Selectivity at other protein targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
transferrin receptor (CD71) Hs Antibody Binding - - - 4-5