elafin   Click here for help

GtoPdb Ligand ID: 12035

Synonyms: cementoin | trappin-2
Immunopharmacology Ligand
Comment: Elafin is a protease inhibitor and it is an endogenous antimicrobial peptide. It is a component of the innate immune response and contributes to controlling microbial infection in mucosal surfaces [1,3-6]. Therapeutic potential of elafin and its precursor trappin-2 is discussed by Deraison et al. (2022) [2].
Species: Human
Bioactivity Comments
Elafin inhibits the elastase proteolytic activity of chymotrypsin like elastase 2A (CELA2).
Selectivity at enzymes
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
chymotrypsin like elastase 2A Ligand is endogenous in the given species Hs Inhibitor Inhibition - - -