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Synonyms: GNC-039 | GNC039
Compound class:
Antibody
Comment: Umizortamig (predicted to be GNC-039, from Systimmune's online pipeline page) is a tetra-specific antibody construct that was designed by the same pharma group as emfizatamab. The main difference between the two constructs is that umizortamig has a domain that recognises epidermal growth factor receptor variant III (EGFRvIII) in place of the CD19 binding domain of emfizatamab. The other 3 recognition domains are the same; CD3E, PD-L1 and 4-1BB (TNFRSF9). Umizortamig is intended to induce immunostimulatory and antineoplastic activities against tumours with the EGFRvIII variant. EGFRvIII is a gain-of-function mutation that arises from genomic deletion of exons 2-7 in the EGFR gene, and is a driver of a proportion of high-grade gliomas such as glioblastoma multiforme (GBM). It is likely that umizortamig is one of the so-called 'guidance and navigation control (GNC)' proteins that are claimed in Sichuan Baili Pharmaceutical/Systimmune patent US20210024630A1 [1].
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| Bioactivity Comments |
| The design and generation of umizortamig has not yet been published (Sep 2022), so there is no quantitative data in the peer-reviewed literature that substantiates its interactions with intended target molecules. |
