spantide I   Click here for help

GtoPdb Ligand ID: 2096

Synonyms: [Arg1,Trp7,9,Leu11]substance P | [D-Arg1,D-Trp7,9,Leu11]-Substance P
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Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
NK1 receptor Cp Antagonist Antagonist 7.0 – 7.1 pA2 - 1-2
pA2 7.0 – 7.1 [1-2]
NK1 receptor Rn Antagonist Antagonist 5.6 pEC50 - 2
pEC50 5.6 Inhibition of histamine release from peritoneal mast cells [2]
NK1 receptor Oc Antagonist Antagonist 8.3 pIC50 - 1
pIC50 8.3 (IC50 5.2x10-9 M) Measuring inhibition of contraction of the rabbit iris sphincter. [1]
NK1 receptor Rn Antagonist Antagonist 5.7 pIC50 - 3
pIC50 5.7 (IC50 2x10-6 M) [3]