N-stearyl-[Nle17]VIP   

GtoPdb Ligand ID: 2271

Synonyms: N-stearyl-[Nle17]vasoactive intestinal peptide
Comment: Synthetic analogue of VIP. The synthesis and characterisation of this peptide was described in [2].
Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
VPAC2 receptor Hs Agonist Agonist 9.0 pIC50 - 1
pIC50 9.0 (IC50 1x10-9 M) [1]
Description: inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor
VPAC1 receptor Rn Agonist Agonist 8.7 pIC50 - 1
pIC50 8.7 (IC50 2x10-9 M) [1]
Description: inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
VPAC2 receptor Rn Agonist Agonist 8.5 pIC50 - 1
pIC50 8.5 (IC50 3x10-9 M) [1]
Description: inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor
VPAC1 receptor Hs Agonist Agonist 8.3 pIC50 - 1
pIC50 8.3 (IC50 5x10-9 M) [1]
Description: inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor