erythropoietin   Click here for help

GtoPdb Ligand ID: 4921

Synonyms: Epogen® | Procrit®
Approved drug
erythropoietin is an approved drug (FDA (no history prior to 1989 available))
Comment: Recombinant forms of human erythropoietin (epoetins), are contained in various approved drugs with INNs that reflect the different glycoform structures formed by different manufacturing processes. The table below provides details of the epoetin alpha originator drug and biosimilars that are currently approved for use by the US FDA and/or the European Medicines Agency (EMA).

Epoetin alpha and biosimilar drugs.

INNTrade names (authorisation holder)First FDA approvalFirst EMA approval
epoetin alfaBinocrit (Sandoz), Abseamed (Medice Arzneimittel Pütter), Epogen (Amgen), Procrit (Janssen)19892007
epoetin betaNeoRecormon, Recormon (both Roche)n/a1997
epoetin zeta (a.k.a. epoetin alfa-epbx)Silapo (Stada Arzneimitte), Retacrit (Hospira)20182007
epoetin thetaBiopoin (Teva), Eporatio (Ratiopharm)n/a2009
Species: Human
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Bioactivity Comments
We have been unable to find publicly available affinity data for this drug at its proposed molecular target to substantiate its MMOA, and have therefore not tagged a primary drug target.
Natural/Endogenous Targets
Eythropoietin receptor
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Eythropoietin receptor Ligand is endogenous in the given species Hs Agonist Agonist 11.1 pIC50 - 1
pIC50 11.1 (IC50 7x10-12 M) [1]
Description: Assay performed using recombinant human EPO