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Synonyms: Apo-3 ligand (Apo3L) | CD255 | TNF-related weak inducer of apoptosis | Tumor necrosis factor ligand superfamily member 12, membrane form
Compound class: Endogenous peptide in human, mouse or rat
Comment: TWEAK protein (TNFSF12) is a tumor necrosis factor (TNF) family cytokine that exists in both membrane-bound and secreted forms. It acts via interaction with the TWEAK receptor (encoded by the TNFRSF12A gene), and is a modulator of endothelial cell proliferation and migration, and is therefore an angiogenesis regulator.