OX-40 ligand   Click here for help

GtoPdb Ligand ID: 5076

Synonyms: glycoprotein Gp34 | TXGP-1
Immunopharmacology Ligand
Comment: OX40L (CD252) is the ligand for tumor necrosis factor receptor superfamily, member 4 (TNFRSF4, a.k.a. OX40 or CD134). OX40 is a secondary co-stimulatory immune checkpoint molecule expressed on activated T cells (requiring CD28 co-stimulatory signal), and OX40L is expressed on activated dendritic cells. The OX40/OX40L pair is involved in late T-cell costimulatory signaling and both are transiently expressed following antigen recognition, and blocking OX40/OX40L is reported to prevent the development of disease in in vivo autoimmune and inflammatory disease models [4]. The OX40/OX40L pathway is being investigated for the development of novel anti-inflammatory therapeutics and anti-cancer drugs.
An antibody binding mouse OX40L
Species: Human
Bioactivity Comments
OX40L is overexpressed in B cells, T cells, and fibroblasts in fibrotic skin of patients with systemic sclerosis (SSc) [1]. The authors suggest that soluble OX40L represents a promising biomarker [3] predictive of worsening fibrosis in these patients. Their in vivo studies in mouse models of SSc indicate that antibody-driven blockade of OX40L protects against inflammatory skin, lung, and vessel fibrosis, and can induce regression of established dermal fibrosis. This mechanism is ineffective in preventing noninflammatory skin fibrosis in a mouse model. These studies used the mouse anti-OX40L monoclonal RM134L. Blockade of OX40L activity has also been reported to be effective against arthritis in mouse models of the disease [2].
Natural/Endogenous Targets
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
OX40 Ligand is endogenous in the given species Hs None - - - -