IL-37   Click here for help

GtoPdb Ligand ID: 6149

Synonyms: IL-1ζ | IL-23 | interleukin-1ζ | interleukin-1-related protein (IL1RP) | interleukin-23
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: IL-37 is an anti-inflammatory cytokine of the innate immune system.
Species: Human
Natural/Endogenous Targets
Target
Interleukin-18 receptor
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Interleukin-18 receptor Ligand is endogenous in the given species Hs Agonist Agonist - - -
⤷
single Ig and TIR domain containing Hs Agonist Agonist - - - 3
⤷ [3]
Description: Interaction determined using fluorescence lifetime imaging–Förster resonance energy transfer (FLIM-FRET) and proximity ligation assay (PLA) studies in LPS-stimulated human PBMCs.